6-trifluoromethyl-1H-indol-3-yl-acetamide → 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-trifluoromethyl-1H-indol-3-yl)pyrrole-2,5-dione

HRID 983983Notes

Reaction equation

HRID 983983 reaction equation
C[O:2][C:3](=O)[C:4]([C:6]1[C:16]2=[C:17]3[C:12](=[CH:13][CH:14]=[CH:15]2)[CH2:11][CH2:10][CH2:9][N:8]3[CH:7]=1)=O.[F:19][C:20]([F:35])([F:34])[C:21]1[CH:29]=[C:28]2[C:24]([C:25]([CH2:30][C:31]([NH2:33])=[O:32])=[CH:26][NH:27]2)=[CH:23][CH:22]=1>>[C:6]1([C:4]2[C:3](=[O:2])[NH:33][C:31](=[O:32])[C:30]=2[C:25]2[C:24]3[C:28](=[CH:29][C:21]([C:20]([F:34])([F:19])[F:35])=[CH:22][CH:23]=3)[NH:27][CH:26]=2)[C:16]2=[C:17]3[C:12](=[CH:13][CH:14]=[CH:15]2)[CH2:11][CH2:10][CH2:9][N:8]3[CH:7]=1

Participants

3

Reactant 2

HCID 219500606-trifluoromethyl-1H-indol-3-yl-acetamideHCID 59298805methyl 2-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-oxoacetate

Product 1

HCID 225568243-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-trifluoromethyl-1H-indol-3-yl)pyrrole-2,5-dione

Procedure

Beginning with (5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester and 6-(trifluoromethyl)indole-3-acetamide, the title compound was prepared essentially as described in Example 1.

Sources & evidence

ORD record
ord-9b518703e62040a98bad02316eae7052
Source dataset
uspto-grants-2005_03
Patent number
US06867198B2

Reaction notes

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