Carbon tetrabromide → HCID 22556832, compound

Participants

Reaction Steps

A solution of 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-[1-(4-hydroxybutyl)-1H-indol-3-yl]pyrrole-2,5-dione (0.11 g, 0.25 mmol) and triphenylphosphine (0.08 g, 0.31 mmol) in dichloromethane (3 mL) was treated with carbon tetrabromide (0.095 g, 0.286 mmol) and stirred for 3 hours. The reaction mixture was then concentrated under reduced pressure and the residue subjected to silica gel chromatography, eluting with 2% methanol in dichloromethane. Fractions containing product were combined and concentrated under reduced pressure to provide 0.101 g (80%) of the title compound as a dark red foam.

Provenance & Evidence