2-(6-fluoro-1H-indol-3-yl)acetamide → 3-(6-Fluoro-1H-indol-3-yl)-4-(5-hydroxymethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-pyrrolidine-2,5-dione

HRID 983992Notes

Reaction equation

HRID 983992 reaction equation
C[O:2][C:3](=O)[C:4]([C:6]1[C:16]2=[C:17]3[C:12](=[CH:13][CH:14]=[CH:15]2)[CH2:11][CH:10]([CH2:18][O:19][Si](C(C)(C)C)(C)C)[CH2:9][N:8]3[CH:7]=1)=O.[F:28][C:29]1[CH:37]=[C:36]2[C:32]([C:33]([CH2:38][C:39]([NH2:41])=[O:40])=[CH:34][NH:35]2)=[CH:31][CH:30]=1>>[F:28][C:29]1[CH:37]=[C:36]2[C:32]([C:33]([CH:38]3[CH:4]([C:6]4[C:16]5=[C:17]6[C:12](=[CH:13][CH:14]=[CH:15]5)[CH2:11][CH:10]([CH2:18][OH:19])[CH2:9][N:8]6[CH:7]=4)[C:3](=[O:2])[NH:41][C:39]3=[O:40])=[CH:34][NH:35]2)=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 219500622-(6-fluoro-1H-indol-3-yl)acetamideHCID 69743275(5-(tert-butyldimethylsilyloxymethyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxo-acetic acid methyl ester

Product 1

HCID 225568043-(6-Fluoro-1H-indol-3-yl)-4-(5-hydroxymethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-pyrrolidine-2,5-dione

Procedure

Beginning with (5-(tert-butyldimethylsilyloxymethyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester and (6-fluoro-1H-indol-3-yl)acetamide, the title compound was prepared essentially as described in Example 1.

Sources & evidence

ORD record
ord-481bd0275b9b4f37a24c087c9e23da40
Source dataset
uspto-grants-2005_03
Patent number
US06867198B2

Reaction notes

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