Indole-3-acetamide → 3-(1H-indol-3-yl)-4-(4-hydroxymethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrrole-2,5-dione

HRID 983996Notes

Reaction equation

HRID 983996 reaction equation
CO[C:3](=[O:20])[C:4]([C:6]1[C:16]2=[C:17]3[C:12](=[CH:13][CH:14]=[CH:15]2)[CH2:11][CH2:10][CH:9]([CH2:18][OH:19])[N:8]3[CH:7]=1)=O.[NH:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:23]([CH2:30][C:31]([NH2:33])=[O:32])=[CH:22]1>>[NH:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:23]([C:30]2[C:31](=[O:32])[NH:33][C:3](=[O:20])[C:4]=2[C:6]2[C:16]3=[C:17]4[C:12](=[CH:13][CH:14]=[CH:15]3)[CH2:11][CH2:10][CH:9]([CH2:18][OH:19])[N:8]4[CH:7]=2)=[CH:22]1

Participants

3

Reactant 2

HCID 397Indole-3-acetamideHCID 69742777(4-hydroxymethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester

Product 1

HCID 102224343-(1H-indol-3-yl)-4-(4-hydroxymethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrrole-2,5-dione

Procedure

Beginning with (4-hydroxymethyl-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester and (1H-indol-3-yl)acetamide, the title compound was prepared essentially as described in Example 1.

Sources & evidence

ORD record
ord-7bf7368200c441c19b800b4371b2022a
Source dataset
uspto-grants-2005_03
Patent number
US06867198B2

Reaction notes

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