(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)acetamide → 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-fluoro-1H-indol-3-yl)pyrrole-2,5-dione

HRID 984002Notes

Reaction equation

HRID 984002 reaction equation
[C:1]1([CH2:13][C:14]([NH2:16])=[O:15])[C:11]2=[C:12]3[C:7](=[CH:8][CH:9]=[CH:10]2)[CH2:6][CH2:5][CH2:4][N:3]3[CH:2]=1.C[O:18][C:19](=O)[C:20]([C:22]1[C:30]2[C:25](=[CH:26][C:27]([F:31])=[CH:28][CH:29]=2)[NH:24][CH:23]=1)=O>>[C:1]1([C:13]2[C:14](=[O:15])[NH:16][C:19](=[O:18])[C:20]=2[C:22]2[C:30]3[C:25](=[CH:26][C:27]([F:31])=[CH:28][CH:29]=3)[NH:24][CH:23]=2)[C:11]2=[C:12]3[C:7](=[CH:8][CH:9]=[CH:10]2)[CH2:6][CH2:5][CH2:4][N:3]3[CH:2]=1

Participants

3

Reactant 2

HCID 16742967(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)acetamideHCID 16762511methyl 2-(6-fluoro-1H-indol-3-yl)-2-oxoacetate

Product 1

HCID 225567763-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-fluoro-1H-indol-3-yl)pyrrole-2,5-dione

Procedure

Beginning with 2-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-acetamide and (6-Fluoro-1H-indol-3-yl)-oxo-acetic acid methyl ester, the title compound was prepared essentially as described in Example 1.

Sources & evidence

ORD record
ord-b3eb1af131e44c9c99f7311d3ff9e8b6
Source dataset
uspto-grants-2005_03
Patent number
US06867198B2

Reaction notes

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