Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isobutanol | HCID 6560 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 3-chloro-4-[chloro(4-chlorophenyl)methyl]phenyl-1,2,4-triazine-3,5(2H,4H)-dione | HCID 22557357 | — |
| Product | HCID 22557345 | HCID 22557345 | 25% |
Reaction Steps
A mixture of 2-[3-chloro-4-[chloro(4-chlorophenyl)methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione (0.0075 mol) and 1,8-diazabicyclo[5.4.0]undec-7-ene (0.025 mol) in 2-methylpropanol (25 ml) was stirred for 72 hours at 80° C. The solvent was evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2/CH3OH 97.5/2.5). The pure fractions were collected and the solvent was evaporated. The residue was dried, yielding 0.8 g (25%) of (±)-2-[3-chloro-4-[(4-chloro-phenyl)(2-methylpropoxy)methyl]phenyl]-1,2,4-triazine-3,5(2H,4H)-dione (compound 133).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06867207B2 |
|---|
| Source dataset | uspto-grants-2005_03 |
|---|
| ORD ID | ord-f4ead90a81d84a6f8e65f1b85c6e77dc |
|---|
| Source note | uspto-grants-2005_03 |
|---|
