Methanol → HCID 11359162, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 800 mg (2.5 mmol) of compound 13 and 101 mg of 60% NaH (2.5 mmol) in 5 ml N,N-dimethyl ethylendiamine was heated in a sealed tube at 120° C. for six hours. To the cooled reaction mixture was carefully added methanol to quench NaH. The resulting mixture was concentrated to dryness, and the residue was purified by flash chromatography (silica gel, 10% MeOH/CH2Cl2 with 1% NH40H) to get 100 mg of compound 14.

Provenance & Evidence