Triethylamine → HCID 22557758, compound

Participants

Reaction Steps

1 g (0.003 mol) of 4-benzyloxy-3-(methansulfonylamino)benzene acetate (WO 96/04233) in 20 ml of methylene chloride, 0.50 ml (0.0033 mol) of 95% benzyl chloroformate, 0.006 g of dimethylaminopyridine and 0.46 ml (0.0033 mol) of triethylamine is stirred at 50° C. for 10 hours. The solvent is evaporated, the residue is taken up in methylene chloride, washing with water is carried out, the two phases are separated, the organic phase is dried over sodium sulfate and filtered, and the solvent is evaporated under reduced pressure. Purification is carried out by chromatography on a column of silica gel, elution being carried out with ethyl acetate. The title compound is obtained.

Provenance & Evidence