反应详情

5-Chloro-2-mercaptobenzoxazole (1 g) was dissolved in toluene (50 ml), N-methylhomopiperazine (3.3 ml) was added dropwise to the solution and then the mixture was stirred with heating for 2 hours. After evaporation of the solvent, the thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1) to obtain the title compound 5-chloro-2-(4-methyl-1-homopiperazinyl)benzoxazole (882 mg).

1. temperaturewith heating for 2 hours
2. customAfter evaporation of the solvent
3. customthe thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1)