HCID 20765969, compound → HCID 20765974, compound

HRID 984104Notes

Reaction equation

HRID 984104 reaction equation
[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH:5]1[CH2:9][C:8]2[CH:10]=[C:11]([S:14](Cl)(=O)=O)[CH:12]=[CH:13][C:7]=2[O:6]1.COC(=O)CC1CC2C=C(SCC3SC(C4C=CC(C(F)(F)F)=CC=4)=NC=3C)C=CC=2O1>>[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH:5]1[CH2:9][C:8]2[CH:10]=[C:11]([SH:14])[CH:12]=[CH:13][C:7]=2[O:6]1

Participants

3

Reactant 2

HCID 20765969HCID 20765969, compound2×HCID 86759614HCID 86759614, compound

Product 1

HCID 20765974HCID 20765974, compound

Procedure

Compound 4D was prepared according to the method of Example 1 utilizing compound 4C. Compound 4D was prepared in 44% yield for 2 steps. MS: 223 (M−1)+. Preparation of {5-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-2,3-dihydro-benzofuran-2-yl}-acetic acid methyl ester (Compound 4E)

Workup

  1. customCompound 4D was prepared

Sources & evidence

ORD record
ord-635ebbd470f34827a603b9831e9cdac3
Source dataset
uspto-grants-2005_03
Patent number
US06867224B2

Reaction notes

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