HuagongsheHuagongshe Chemistry Print Report · For research reference only
{6-[4-Methyl-2-(4-Trifluoromethyl-Phenyl)-Thiazol-5-Ylmethylsulfanyl]-3,4-Dihydro-1H-Isoquinolin-2-Yl}-Acetic Acid Methyl Ester → (6-Mercapto-3,4-Dihydro-1H-Isoquinolin-2-Yl)-Acetic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | {6-[4-Methyl-2-(4-Trifluoromethyl-Phenyl)-Thiazol-5-Ylmethylsulfanyl]-3,4-Dihydro-1H-Isoquinolin-2-Yl}-Acetic Acid Methyl Ester | HCID 20765977 | — |
| Reactant | 5-Mercapto-Indan-2-Carboxylic Acid Methyl Ester | HCID 20766012 | — |
| Product | (6-Mercapto-3,4-Dihydro-1H-Isoquinolin-2-Yl)-Acetic Acid Methyl Ester | HCID 20765990 | 74% |
Reaction Steps
10C was prepared analogously to compound 1C. 74% yield. MS: 238 (M+1)+. Preparation of {6-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-3,4-dihydro-1H-isoquinolin-2-yl}-acetic acid methyl ester (Compound 10D)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06867224B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-4f1205f008e24ec1a2cac2a5ffcf942c |
| Source note | uspto-grants-2005_03 |