5-Mercapto-Indan-2-Carboxylic Acid Methyl Ester → (6-Mercapto-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-acetic acid methyl ester

HRID 984112Notes

Reaction equation

HRID 984112 reaction equation
COC(C1CC2C(=CC=C(S)C=2)C1)=O.[CH3:15][O:16][C:17](=[O:48])[CH2:18][N:19]1[C:28]2[C:23](=[CH:24][C:25]([S:29]CC3SC(C4C=CC(C(F)(F)F)=CC=4)=NC=3C)=[CH:26][CH:27]=2)[CH2:22][CH2:21][C:20]1=[O:47]>>[CH3:15][O:16][C:17](=[O:48])[CH2:18][N:19]1[C:28]2[C:23](=[CH:24][C:25]([SH:29])=[CH:26][CH:27]=2)[CH2:22][CH2:21][C:20]1=[O:47]

Participants

3

Reactant 2

HCID 207660125-Mercapto-Indan-2-Carboxylic Acid Methyl EsterHCID 69590773{6-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-2-oxo-3,4-dihydro-2H-quinolin-1-yl}-acetic acid methyl ester2×

Product 1

HCID 20770803(6-Mercapto-2-oxo-3,4-dihydro-2H-quinolin-1-yl)-acetic acid methyl esterYield 92%

Procedure

12C was prepared analogously to compound 1C. 92% yield. MS: 252 (M+1)+. Preparation of {6-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-2-oxo-3,4-dihydro-2H-quinolin-1-yl}-acetic acid methyl ester (Compound 12D)

Sources & evidence

ORD record
ord-3c731d1e71e8448ea1149349ca2f49d3
Source dataset
uspto-grants-2005_03
Patent number
US06867224B2

Reaction notes

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