7-Methyl-6-[4-methyl-2-(4-trifluoromethyl-pheny)-thiazol-5-ylmethylsulfanyl]-chroman-2-yl-acetic acid methyl ester → 6-Mercapto-7-methyl-chroman-2-yl-acetic acid methyl ester

HRID 984117Notes

Reaction equation

HRID 984117 reaction equation
SC1C=C2C(=CC=1C)OC(O)CC2.[CH3:14][O:15][C:16](=[O:47])[CH2:17][CH:18]1[CH2:27][CH2:26][C:25]2[C:20](=[CH:21][C:22]([CH3:46])=[C:23]([S:28]CC3SC(C4C=CC(C(F)(F)F)=CC=4)=NC=3C)[CH:24]=2)[O:19]1>>[CH3:14][O:15][C:16](=[O:47])[CH2:17][CH:18]1[CH2:27][CH2:26][C:25]2[C:20](=[CH:21][C:22]([CH3:46])=[C:23]([SH:28])[CH:24]=2)[O:19]1

Participants

3

Reactant 2

HCID 207659967-Methyl-6-[4-methyl-2-(4-trifluoromethyl-pheny)-thiazol-5-ylmethylsulfanyl]-chroman-2-yl-acetic acid methyl ester2×HCID 21949446HCID 21949446, compound

Product 1

HCID 207659976-Mercapto-7-methyl-chroman-2-yl-acetic acid methyl ester

Procedure

Compound 15D was prepared according to the method of example 1D utilizing compound 15C. MS: 251 (M−1)+. Preparation of 7-Methyl-6-[4-methyl-2-(4-trifluoromethyl-pheny)-thiazol-5-ylmethylsulfanyl]-chroman-2-yl-acetic acid methyl ester (Compound 15E)

Sources & evidence

ORD record
ord-0d087ecb3b6a47999358ddd92f6a2887
Source dataset
uspto-grants-2005_03
Patent number
US06867224B2

Reaction notes

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