HCID 20766013, compound → HCID 20237138, compound

HRID 984119Notes

Reaction equation

HRID 984119 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH2:6][O:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([S:15](Cl)(=O)=O)=[CH:10][CH:9]=2)=[O:4].COC(C1COC2C(C=1)=CC(SCC1SC(C3C=CC(C(F)(F)F)=CC=3)=NC=1C)=CC=2)=O>>[CH3:1][O:2][C:3]([C:5]1[CH2:6][O:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([SH:15])=[CH:10][CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 20766013HCID 20766013, compound2×HCID 20766015HCID 20766015, compound

Product 1

HCID 20237138HCID 20237138, compound

Procedure

Compound 16E was prepared according to the method of example 1C utilizing compound 16D. Compound 16E was prepared in 20% yield. MS: 221 (M−1)+. Preparation of 6-[4-Methyl-2-(4-trifluoromethyl-pheny)-thiazol-5-ylmethylsulfanyl]-2H-chromene-3-carboxylic acid methyl ester (Compound 16F)

Workup

  1. customCompound 16E was prepared

Sources & evidence

ORD record
ord-fa0fe97e74fe413b82964f7f212cd8f9
Source dataset
uspto-grants-2005_03
Patent number
US06867224B2

Reaction notes

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