HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-[4-Methyl-2-(4-trifluoromethyl-pheny)-thiazol-5-ylmethylsulfanyl]-chroman-3-carboxylic acid methyl ester → 6-Mercapto-chroman-3-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-[4-Methyl-2-(4-trifluoromethyl-pheny)-thiazol-5-ylmethylsulfanyl]-chroman-3-carboxylic acid methyl ester | HCID 10238861 | — |
| Reactant | Methyl 6-(chlorosulfonyl)chromane-3-carboxylate | HCID 20766016 | — |
| Product | 6-Mercapto-chroman-3-carboxylic acid methyl ester | HCID 20766019 | 85% |
Reaction Steps
Compound 17C was prepared according to the method of example 1C utilizing compound 17B. Compound PPC was prepared in 85% yield. mp 83-84° C.; MS: 223 (M−1)+. Preparation of 6-[4-Methyl-2-(4-trifluoromethyl-pheny)-thiazol-5-ylmethylsulfanyl]-chroman-3-carboxylic acid methyl ester (Compound 17D)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06867224B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-27ccf792f1624bb9bb7a528b837cc9d8 |
| Source note | uspto-grants-2005_03 |