反应详情

Compound 18A (3.6 g) was dissolved in pyridine (11 mL) at RT. Toluene sulfonyl chloride (4.5 g) was added, stirred for 6 h. The reaction mixture was quenched with 2N HCl (500 mL), ether extraction (2×200 mL). The combined ether was washed with water, brine, dried (MgSO4), concentrated, to afford an orange color solid, compound 18B (4.2 g). mp 83-84° C.; MS: 319 (M+1)+. Preparation of Chroman-3-yl-acetonitrile (Compound 18C)

1. customThe reaction mixture was quenched with 2N HCl (500 mL), ether extraction (2×200 mL)
2. washThe combined ether was washed with water, brine
3. dry with materialdried (MgSO4)
4. concentrationconcentrated