HCID 20765983, compound → HCID 20765967, compound

HRID 984126Notes

Reaction equation

HRID 984126 reaction equation
[CH3:1][O:2][C:3](=[O:20])[CH2:4][CH:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([S:16](Cl)(=O)=O)[CH:12]=2)[O:7][CH2:6]1.COC(=O)C=C1C(=O)C2C(=CC=C(SCC3SC(C4C=CC(C(F)(F)F)=CC=4)=NC=3C)C=2)OC1>>[CH3:1][O:2][C:3](=[O:20])[CH2:4][CH:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([SH:16])[CH:12]=2)[O:7][CH2:6]1

Participants

3

Reactant 2

HCID 20765983HCID 20765983, compoundHCID 131724782HCID 131724782, compound2×

Product 1

HCID 20765967HCID 20765967, compound

Procedure

Compound 20D was prepared according to the method of example 1C utilizing compound 20C. Compound 20D was prepared in 75% yield. MS: 251 (M−1)+. Preparation of 6-[4-Methyl-2-(4-trifluoromethyl-pheny)-thiazol-5-ylmethylsulfanyl]-4-oxo-chroman-3-ylidene-acetic acid methyl ester (Compound 20E)

Workup

  1. customCompound 20D was prepared

Sources & evidence

ORD record
ord-4ce5a9063dcc4e5bb4af5d79aa3efc69
Source dataset
uspto-grants-2005_03
Patent number
US06867224B2

Reaction notes

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