Sodium borohydride → HCID 20766002, compound

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Reaction Steps

Sodium borohydride (0.6 g) was added to a solution of compound 21B (0.65 g) in 20 mL of MeOH at 0° C. by portion in 15 minutes period. The mixture was stirred for another 30 minutes at RT, quenched with 50 mL of water and 50 mL of ether. The organic layer was separated, washed with water, brine, dried (MgSO4), concentrated to afford compound 21C (0.42 g). MS: 236 (M−1)+. Preparation of 3-{5-[4-Methyl-2-(4-trifluoromethyl-pheny)-thiazol-5-ylmethylsulfanyl]-2,3-dihydro-indol-1-yl}-propionic acid methyl ester (Compound 21D)

Provenance & Evidence