Methyl bromoacetate → HCID 20765987, compound

Participants

Reaction Steps

The KN(TMS)2 (7.2 g) was added to a solution of compound 22B (4 g) in 150 mL of THF at 0° C. by portion, another one hour at 0° C. with stirring. Methyl bromoacetate (7 g) was added, stirred at RT overnight. The reaction mixture was quenched with 150 mL of ethyl acetate and 100 mL of 2N HCl. The organic layer was separated, washed with water, brine, dried (MgSO4), concentrated to afford an off-white solid compound 22C (2.5 g). mp 185-188° C.; MS: 238 (M+1)+. Preparation of 5-Chlorosulfonyl-6-methoxy-3-oxo-3H-benzo[d]isoxazol-2-yl-acetic acid methyl ester (Compound 22D)

Provenance & Evidence