HCID 20765971, compound → HCID 20765986, compound

HRID 984129Notes

Reaction equation

HRID 984129 reaction equation
[CH3:1][O:2][C:3](=[O:21])[CH2:4][N:5]1[C:9](=[O:10])[C:8]2[CH:11]=[C:12]([S:17](Cl)(=O)=O)[C:13]([O:15][CH3:16])=[CH:14][C:7]=2[O:6]1.COC(=O)CN1C(=O)C2C=C(SCC3SC(C4C=CC(C(F)(F)F)=CC=4)=NC=3C)C(OC)=CC=2O1>>[CH3:1][O:2][C:3](=[O:21])[CH2:4][N:5]1[C:9](=[O:10])[C:8]2[CH:11]=[C:12]([SH:17])[C:13]([O:15][CH3:16])=[CH:14][C:7]=2[O:6]1

Participants

3

Reactant 2

HCID 20765971HCID 20765971, compoundHCID 20765988HCID 20765988, compound2×

Product 1

HCID 20765986HCID 20765986, compound

Procedure

Compound 22E was prepared according to the method of example 1C utilizing compound 22D. Compound 22E was prepared in 10% yield. MS: 268 (M−1)+. Preparation of 6-Methoxy-5-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-3-oxo-3H-benzo[d]isoxazol-2-yl-acetic acid methyl ester (Compound 22F)

Workup

  1. customCompound 22E was prepared

Sources & evidence

ORD record
ord-6eee10400c484ac3a97baed83dd3515c
Source dataset
uspto-grants-2005_03
Patent number
US06867224B2

Reaction notes

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