Water → HCID 21054917, compound

HRID 984131Notes

Reaction equation

HRID 984131 reaction equation
[CH3:1][O:2][C:3](=[O:17])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([S:14]C#N)=[CH:11][CH:12]=2)[CH2:7][CH2:6]1.O.SCC(O)=O>CO>[CH3:1][O:2][C:3](=[O:17])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([SH:14])=[CH:11][CH:12]=2)[CH2:7][CH2:6]1

Participants

5

Reactant 3

HCID 962WaterHCID 1133Thioglycolic AcidHCID 21054918HCID 21054918, compound

Product 1

HCID 21054917HCID 21054917, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Compound 25B (1.05 g, 4.2 mmol) was refluxed in a solution of water (2 ml), methanol (20 ml) and mercaptoacetic acid (1.2 g, 13 mmol) for 3 h. The solvent was removed under the vacuo, and the crude product was passed a short silica gel chromatography to give 25C in 95% yield.

Workup

  1. customThe solvent was removed under the vacuo

Sources & evidence

ORD record
ord-4d5f90d1a6e24222810c8df91fc51586
Source dataset
uspto-grants-2005_03
Patent number
US06867224B2

Reaction notes

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