1,4-Dioxa-8-azaspiro(4.5)decane → 1-[[2-(3,5-Dimethoxy-4-isopropoxyphenyl)pyridin-4-yl]methyl]-4-piperidone ethylene ketal

HRID 984177Notes

Reaction equation

HRID 984177 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH:18]([CH3:20])[CH3:19])=[C:11]([O:21][CH3:22])[CH:10]=2)[CH:4]=1.[CH2:23]1[O:32][C:26]2([CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[O:25][CH2:24]1>>[CH2:23]1[O:32][C:26]2([CH2:31][CH2:30][N:29]([CH2:2][C:3]3[CH:8]=[CH:7][N:6]=[C:5]([C:9]4[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH:18]([CH3:20])[CH3:19])=[C:11]([O:21][CH3:22])[CH:10]=4)[CH:4]=3)[CH2:28][CH2:27]2)[O:25][CH2:24]1

Participants

3

Reactant 2

HCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 22558034HCID 22558034, compound

Product 1

HCID 213388361-[[2-(3,5-Dimethoxy-4-isopropoxyphenyl)pyridin-4-yl]methyl]-4-piperidone ethylene ketal

Procedure

4-Chloromethyl-2-(3,5-dimethoxy-4-isopropoxyphenyl)pyridine (643 mg) and 4-piperidone ethylene ketal (287 mg) were coupled in the same manner as described in Example 2 to give the title compound.

Sources & evidence

ORD record
ord-6809f45f7a2e46b2baf3894e894bdb9f
Source dataset
uspto-grants-2005_03
Patent number
US06867221B2

Reaction notes

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