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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 984194Generated: October 31, 2026

1,3-Benzodioxol-5-amine → 4-(3,4-Methylenedioxyphenylamino)-1-[[2-(3,4,5-trimethoxyphenyl) pyridin-4-yl]methyl]piperidine

https://huagongshe.com/reaction/984194

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-Benzodioxol-5-amineHCID 84310—
Reactant[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl-4-piperidoneHCID 22557811—
Product4-(3,4-Methylenedioxyphenylamino)-1-[[2-(3,4,5-trimethoxyphenyl) pyridin-4-yl]methyl]piperidineHCID 12043487—

Reaction Steps

1-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl-4-piperidone (1.40 g) and 3,4-methylenedioxyaniline (646 mg) were treated in the same manner as described in Preparation Example 29 to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06867221B2
Source datasetuspto-grants-2005_03
ORD IDord-dc4776670e484afeba9de49d8313a0c9
Source noteuspto-grants-2005_03