HRID984196

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12016329

未命名化合物

结构：COc1cc(-c2cc(CN3CCC(Nc4ccc5c(c4)OCO5)CC3)ccn2)cc(OC)c1OC

HCID12043487

未命名化合物

PRODUCTS

生成物

结构：COc1cc(-c2cc(CN3CCC(N(Cc4ccccc4-c4cc(OC)c(OC)c(OC)c4)c4ccc5c(c4)OCO5)CC3)ccn2)cc(OC)c1OC.Cl.Cl

HCID18174250

未命名化合物

PROCEDURE

实验过程

4-(3,4-Methylenedioxyphenylamino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine (119 mg) and 2-(3,4,5-trimethoxyphenyl)benzyl chloride (114 mg) were condensed in the same manner as described in Example 9. A free base obtained was converted to a dihydrochloroide to give the title compound as yellow powder.

WORKUP

后处理

customcondensed in the same manner
customA free base obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6a6b59a6f5e04e41acd0567ec045dfba
来源数据集: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06867221B2
来源说明: uspto-grants-2005_03

反应 SMILES

[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([NH:10][CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][C:18]4[CH:23]=[CH:22][N:21]=[C:20]([C:24]5[CH:29]=[C:28]([O:30][CH3:31])[C:27]([O:32][CH3:33])=[C:26]([O:34][CH3:35])[CH:25]=5)[CH:19]=4)[CH2:13][CH2:12]3)=[CH:4][C:3]=2[O:2]1.[CH3:36][O:37][C:38]1[CH:39]=[C:40]([C:48]2[CH:55]=[CH:54][CH:53]=[CH:52][C:49]=2[CH2:50][Cl:51])[CH:41]=[C:42]([O:46][CH3:47])[C:43]=1[O:44][CH3:45]>>[ClH:51].[ClH:51].[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([N:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][C:18]4[CH:23]=[CH:22][N:21]=[C:20]([C:24]5[CH:25]=[C:26]([O:34][CH3:35])[C:27]([O:32][CH3:33])=[C:28]([O:30][CH3:31])[CH:29]=5)[CH:19]=4)[CH2:13][CH2:12]3)[CH2:50][C:49]3[CH:52]=[CH:53][CH:54]=[CH:55][C:48]=3[C:40]3[CH:41]=[C:42]([O:46][CH3:47])[C:43]([O:44][CH3:45])=[C:38]([O:37][CH3:36])[CH:39]=3)=[CH:4][C:3]=2[O:2]1