HRID984204

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12019237

4-chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine

C15H16ClNO3

结构：COc1cc(-c2cc(CN(C)C3CCNCC3)ccn2)cc(OC)c1OC

HCID22557863

未命名化合物

PRODUCTS

生成物

结构：COc1cc(-c2cc(CN3CCC(N(C)Cc4ccnc(-c5cc(OC)c(OC)c(OC)c5)c4)CC3)ccn2)cc(OC)c1OC.Cl.Cl.Cl.Cl

HCID22557939

未命名化合物

PROCEDURE

实验过程

4-[N-methyl-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]amino]piperidine (73 mg) and 4-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (58 mg) were condensed in the same manner as described in Example 2. The title compound was obtained after converting a free base to a tetrahydrochloride.

WORKUP

后处理

customcondensed in the same manner

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-aa677b044ce744dabb2744136db09c94
来源数据集: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06867221B2
来源说明: uspto-grants-2005_03

反应 SMILES

[CH3:1][N:2]([CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)[CH2:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10]2[CH:15]=[C:14]([O:16][CH3:17])[C:13]([O:18][CH3:19])=[C:12]([O:20][CH3:21])[CH:11]=2)[CH:5]=1.[Cl:28][CH2:29][C:30]1[CH:35]=[CH:34][N:33]=[C:32]([C:36]2[CH:41]=[C:40]([O:42][CH3:43])[C:39]([O:44][CH3:45])=[C:38]([O:46][CH3:47])[CH:37]=2)[CH:31]=1>>[ClH:28].[ClH:28].[ClH:28].[ClH:28].[CH3:1][N:2]([CH:22]1[CH2:27][CH2:26][N:25]([CH2:29][C:30]2[CH:35]=[CH:34][N:33]=[C:32]([C:36]3[CH:41]=[C:40]([O:42][CH3:43])[C:39]([O:44][CH3:45])=[C:38]([O:46][CH3:47])[CH:37]=3)[CH:31]=2)[CH2:24][CH2:23]1)[CH2:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10]2[CH:11]=[C:12]([O:20][CH3:21])[C:13]([O:18][CH3:19])=[C:14]([O:16][CH3:17])[CH:15]=2)[CH:5]=1