Aniline → HCID 22557918, compound

HRID 984212Notes

Reaction equation

HRID 984212 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([C:10]2[CH:15]=[C:14]([CH2:16][N:17]3[CH2:22][CH2:21][C:20](=O)[CH2:19][CH2:18]3)[CH:13]=[CH:12][N:11]=2)=[CH:4][C:3]=1[O:24][CH3:25].[NH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[NH:26]([CH:20]1[CH2:21][CH2:22][N:17]([CH2:16][C:14]2[CH:13]=[CH:12][N:11]=[C:10]([C:5]3[CH:4]=[C:3]([O:24][CH3:25])[C:2]([Cl:1])=[C:7]([O:8][CH3:9])[CH:6]=3)[CH:15]=2)[CH2:18][CH2:19]1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 6115AnilineHCID 22558037HCID 22558037, compound

Product 1

HCID 22557918HCID 22557918, compound

Procedure

1-[[2-(4-Chloro-3,5-dimethoxyphenyl)pyridin-4-yl]methyl]-4-piperidone (600 mg) and aniline (0.18 mL) were reacted in the same manner as described in Preparation Example 37 to give the title compound.

Workup

  1. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-f488aac2cdc1473e88f015fd68ce9458
Source dataset
uspto-grants-2005_03
Patent number
US06867221B2

Reaction notes

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