HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine → 4-[N-(3-Methylthiophenyl)-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-3-yl]methyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine Trihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine | HCID 12043146 | — |
| Reactant | 4-(3-Methylthioanilino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine | HCID 22557887 | — |
| Product | 4-[N-(3-Methylthiophenyl)-N-[[2-(3,4,5-trimethoxyphenyl)pyridin-3-yl]methyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine Trihydrochloride | HCID 68918607 | — |
Reaction Steps
4-(3-Methylthioanilino)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine (143 mg) and 3-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (114 mg) were condensed in the same manner as described in Example 9. The title compound was obtained as yellow powder after converting a free base to a trihydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06867221B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-936fda93faeb4b5aa356289d4e97bacd |
| Source note | uspto-grants-2005_03 |