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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 984246Generated: October 30, 2026

3-(3,4,5-Trimethoxyphenyl)benzyl chloride → 1-(tert-butoxycarbonyl)-4-[N-(4-ethoxyphenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]piperidine

https://huagongshe.com/reaction/984246

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(3,4,5-Trimethoxyphenyl)benzyl chlorideHCID 12021157—
Reactant1-Boc-4-[(4-ethoxyphenyl)amino]-piperidineHCID 22557860—
Product1-(tert-butoxycarbonyl)-4-[N-(4-ethoxyphenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]piperidineHCID 22557829—

Reaction Steps

1-(tert-Butoxycarbonyl)-4-[(4-ethoxyphenyl)amino]piperidine (641 mg) and 3-(3,4,5-trimethoxyphenyl)benzyl chloride (586 mg) was treated in the same manner as described in Example 9 to give light yellow amorphous of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06867221B2
Source datasetuspto-grants-2005_03
ORD IDord-27d2bd59a8224604a19c04f880c12d8a
Source noteuspto-grants-2005_03