4-Butyloxyaniline → 1-(Tert-butoxycarbonyl)-4-(4-butoxyphenylamino)piperidine

HRID 984247Notes

Reaction equation

HRID 984247 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:15]([O:19][C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][CH:21]=1)[CH2:16][CH2:17][CH3:18]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:24][C:23]2[CH:22]=[CH:21][C:20]([O:19][CH2:15][CH2:16][CH2:17][CH3:18])=[CH:26][CH:25]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 203524-ButyloxyanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 225579441-(Tert-butoxycarbonyl)-4-(4-butoxyphenylamino)piperidine

Procedure

1-(tert-butoxycarbonyl)-4-piperidone (5.00 g) and 4-butoxyaniline (3.95 g) was treated in the same manner as described in Preparation Example 37 to give brown powder of the title compound.

Workup

  1. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-ab65b7b7399240ffb40a974dc86376ac
Source dataset
uspto-grants-2005_03
Patent number
US06867221B2

Reaction notes

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