3-Methoxyaniline → Tert-butyl 4-(3-methoxyanilino)piperidine-1-carboxylate

HRID 984251Notes

Reaction equation

HRID 984251 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:15][O:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([NH2:23])[CH:18]=1>>[CH3:15][O:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][CH:11]2[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:9][CH2:10]2)[CH:18]=1

Participants

3

Reactant 2

HCID 108243-MethoxyanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 22557965Tert-butyl 4-(3-methoxyanilino)piperidine-1-carboxylate

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (4.78 g) and m-anisidine (2.96 g) were condensed in the same manner as described in Preparation Example 37 to give the title compound.

Workup

  1. customcondensed in the same manner
  2. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-f20dfa4df1d04aa795351d55cd3ddff7
Source dataset
uspto-grants-2005_03
Patent number
US06867221B2

Reaction notes

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