4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine → 1-(tert-butoxycarbonyl)-4-[N-(3-methoxyphenyl)-N-[[2-(3,4,5-trimethoxyphenyl) pyridin-4-yl]methyl]amino]piperidine

Participants

Role	Name	HCID	Charge
Reactant	4-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine	HCID 12019237	—
Reactant	Tert-butyl 4-(3-methoxyanilino)piperidine-1-carboxylate	HCID 22557965	—
Product	1-(tert-butoxycarbonyl)-4-[N-(3-methoxyphenyl)-N-[[2-(3,4,5-trimethoxyphenyl) pyridin-4-yl]methyl]amino]piperidine	HCID 22557960	—

Reaction Steps

4-(m-Anisidino)-1-(tert-butoxycarbonyl)piperidine (613 mg) and 4-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (588 mg) was treated in the same manner as described in Example 9 to give light yellow amorphous of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06867221B2
Source dataset	uspto-grants-2005_03
ORD ID	ord-170ac27b4a81414e8b5ca0002de635b1
Source note	uspto-grants-2005_03