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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 984253Generated: October 29, 2026

3-Chloromethyl-5-(3,4,5-trimethoxyphenyl)pyridine → 1-(tert-butoxycarbonyl)-4-[N-(3-methoxyphenyl)-N-[[3-(3,4,5-trimethoxyphenyl) pyridin-5-yl]methyl]amino]piperidine

https://huagongshe.com/reaction/984253

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloromethyl-5-(3,4,5-trimethoxyphenyl)pyridineHCID 22557874—
ReactantTert-butyl 4-(3-methoxyanilino)piperidine-1-carboxylateHCID 22557965—
Product1-(tert-butoxycarbonyl)-4-[N-(3-methoxyphenyl)-N-[[3-(3,4,5-trimethoxyphenyl) pyridin-5-yl]methyl]amino]piperidineHCID 22557785—

Reaction Steps

4-(m-Anisidino)-1-(tert-butoxycarbonyl)piperidine (613 mg) and 5-chloromethyl-3-(3,4,5-trimethoxyphenyl)pyridine (588 mg) was treated in the same manner as described in Example 9 to give light yellow amorphous of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06867221B2
Source datasetuspto-grants-2005_03
ORD IDord-b9df14cebeba413fac45fa27f618f76a
Source noteuspto-grants-2005_03