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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 984258Generated: October 30, 2026

3-(3,4,5-Trimethoxyphenyl)benzyl chloride → 1-(tert-butoxycarbonyl)-4-[N-(2-methoxyphenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]piperidine

https://huagongshe.com/reaction/984258

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(3,4,5-Trimethoxyphenyl)benzyl chlorideHCID 12021157—
Reactanttert-Butyl 4-((2-methoxyphenyl)amino)piperidine-1-carboxylateHCID 22557919—
Product1-(tert-butoxycarbonyl)-4-[N-(2-methoxyphenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]piperidineHCID 22557938—

Reaction Steps

4-(o-Anisidino)-1-(tert-butoxycarbonyl)piperidine (613 mg) and 3-(3,4,5-trimethoxyphenyl)benzyl chloride (586 mg) was treated in the same manner as described in Example 9 to give light yellow amorphous of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06867221B2
Source datasetuspto-grants-2005_03
ORD IDord-000140c9b1aa497c806e6ba7f7ddd1cc
Source noteuspto-grants-2005_03