2,3-Dimethoxyaniline → 1-(Tert-butoxycarbonyl)-4-(2,3-dimethoxyphenylamino)piperidine

HRID 984259Notes

Reaction equation

HRID 984259 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:15][O:16][C:17]1[C:23]([O:24][CH3:25])=[CH:22][CH:21]=[CH:20][C:18]=1[NH2:19]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:19][C:18]2[CH:20]=[CH:21][CH:22]=[C:23]([O:24][CH3:25])[C:17]=2[O:16][CH3:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 2396032,3-DimethoxyanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 225578701-(Tert-butoxycarbonyl)-4-(2,3-dimethoxyphenylamino)piperidine

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (4.78 g) and 2,3-dimethoxyaniline (3.68 g) were condensed in the same manner as described in Preparation Example 37 to give the title compound.

Workup

  1. customcondensed in the same manner
  2. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-d1a348f00c284cf1930ee691bfe67903
Source dataset
uspto-grants-2005_03
Patent number
US06867221B2

Reaction notes

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