4-(Methylthio)aniline → 1-(Tert-butoxycarbonyl)-4-[[4-(methylthio)phenyl]amino]piperidine

HRID 984266Notes

Reaction equation

HRID 984266 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:15][S:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:21][C:20]2[CH:22]=[CH:23][C:17]([S:16][CH3:15])=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 660384-(Methylthio)anilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 225580351-(Tert-butoxycarbonyl)-4-[[4-(methylthio)phenyl]amino]piperidine

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (5.00 g) and 4-(methylthio)aniline (3.33 g) was treated in the same manner as described in Preparation Example 37 to give white powder of the title compound.

Workup

  1. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-b75008a698fb4b71abec7229965a294a
Source dataset
uspto-grants-2005_03
Patent number
US06867221B2

Reaction notes

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