HRID984276

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12021157

未命名化合物

结构：CC(C)(C)OC(=O)N1CCC(Nc2ccc(C(F)(F)F)cc2)CC1

HCID22029142

tert-Butyl 4-[4-(trifluoromethyl)anilino]piperidine-1-carboxylate

C17H23F3N2O2

PRODUCTS

生成物

结构：COc1cc(-c2cccc(CN(c3ccc(C(F)(F)F)cc3)C3CCN(C(=O)OC(C)(C)C)CC3)c2)cc(OC)c1OC

HCID22558019

未命名化合物

PROCEDURE

实验过程

1-(tert-Butoxycarbonyl)-4-[[4-(trifluoromethyl)phenyl]amino]piperidine (689 mg) and 3-(3,4,5-trimethoxyphenyl)benzyl chloride (586 mg) was treated in the same manner as described in Example 9 to give light yellow amorphous of the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a5156e6cd1644ec3a73d96964ba41c84
来源数据集: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06867221B2
来源说明: uspto-grants-2005_03

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:25][O:26][C:27]1[CH:28]=[C:29]([C:37]2[CH:38]=[C:39]([CH:42]=[CH:43][CH:44]=2)[CH2:40]Cl)[CH:30]=[C:31]([O:35][CH3:36])[C:32]=1[O:33][CH3:34]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([C:15]2[CH:16]=[CH:17][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:19][CH:20]=2)[CH2:40][C:39]2[CH:42]=[CH:43][CH:44]=[C:37]([C:29]3[CH:30]=[C:31]([O:35][CH3:36])[C:32]([O:33][CH3:34])=[C:27]([O:26][CH3:25])[CH:28]=3)[CH:38]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]