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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 984281Generated: October 26, 2026

4-Chloroaniline → Tert-butyl 4-(4-chlorophenylamino)piperidine-1-carboxylate

https://huagongshe.com/reaction/984281

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-ChloroanilineHCID 7812—
Reactanttert-Butyl 4-oxopiperidine-1-carboxylateHCID 735900—
ProductTert-butyl 4-(4-chlorophenylamino)piperidine-1-carboxylateHCID 1491503—

Reaction Steps

1-(tert-Butoxycarbonyl)-4-piperidone (5.00 g) and 4-chloroaniline (3.05 g) was treated in the same manner as described in Preparation Example 37 to give white powder of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06867221B2
Source datasetuspto-grants-2005_03
ORD IDord-f94b60ea74bb454684dced03a68c0298
Source noteuspto-grants-2005_03