3-Chloromethyl-5-(3,4,5-trimethoxyphenyl)pyridine → 1-(tert-butoxycarbonyl)-4-[N-(3,4-difluorophenyl)-N-[[3-(3,4,5-trimethoxyphenyl) pyridin-5-yl]methyl]amino]piperidine

Participants

Role	Name	HCID	Charge
Reactant	3-Chloromethyl-5-(3,4,5-trimethoxyphenyl)pyridine	HCID 22557874	—
Reactant	1-Boc-4-[(3,4-difluorophenyl)amino]-piperidine	HCID 22558033	—
Product	1-(tert-butoxycarbonyl)-4-[N-(3,4-difluorophenyl)-N-[[3-(3,4,5-trimethoxyphenyl) pyridin-5-yl]methyl]amino]piperidine	HCID 22557885	—

Reaction Steps

1-(tert-Butoxycarbonyl)-4-[(3,4-difluorophenyl)amino]piperidine (625 mg) and 5-chloromethyl-3-(3,4,5-trimethoxyphenyl)pyridine (588 mg) was treated in the same manner as described in Example 9 to give light yellow amorphous of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06867221B2
Source dataset	uspto-grants-2005_03
ORD ID	ord-555f8145774b47448470c70870a9adf3
Source note	uspto-grants-2005_03