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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 984291Generated: October 30, 2026

3-(3,4,5-Trimethoxyphenyl)benzyl chloride → 1-(tert-butoxycarbonyl)-4-[N-(4-fluorophenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]piperidine

https://huagongshe.com/reaction/984291

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(3,4,5-Trimethoxyphenyl)benzyl chlorideHCID 12021157—
Reactanttert-Butyl 4-(4-fluoroanilino)piperidine-1-carboxylateHCID 16413902—
Product1-(tert-butoxycarbonyl)-4-[N-(4-fluorophenyl)-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]piperidineHCID 22557865—

Reaction Steps

1-(tert-Butoxycarbonyl)-4-[(4-fluorophenyl)amino]piperidine (589 mg) and 3-(3,4,5-trimethoxyphenyl)benzyl chloride (586 mg) was treated in the same manner as described in Example 9 to give light yellow amorphous of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06867221B2
Source datasetuspto-grants-2005_03
ORD IDord-6f2d4a5b433a42f3ad16e80386937d63
Source noteuspto-grants-2005_03