Aniline → 1-Boc-4-AP

HRID 984292Notes

Reaction equation

HRID 984292 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 6115AnilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 14915021-Boc-4-AP

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (5.00 g) and aniline (2.23 g) was treated in the same manner as described in Preparation Example 37 to give white needles of the title compound.

Workup

  1. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-99d8b8137399427f8b92693d36e73a87
Source dataset
uspto-grants-2005_03
Patent number
US06867221B2

Reaction notes

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