tert-butyl 4-(4-methoxyanilino)tetrahydro-1(2H)-pyridinecarboxylate → 1-(tert-butoxycarbonyl)-4-[N-(4-methoxyphenyl)-N-[[2-(3,4-dimethoxyphenyl)pyridin-4-yl]methyl]amino]piperidine

Participants

Role	Name	HCID	Charge
Reactant	tert-butyl 4-(4-methoxyanilino)tetrahydro-1(2H)-pyridinecarboxylate	HCID 2776119	—
Reactant	4-Chloromethyl-2-(3,4-dimethoxyphenyl)pyridine	HCID 22558069	—
Product	1-(tert-butoxycarbonyl)-4-[N-(4-methoxyphenyl)-N-[[2-(3,4-dimethoxyphenyl)pyridin-4-yl]methyl]amino]piperidine	HCID 22557846	—

Reaction Steps

4-(p-Anisidino)-1-(tert-butoxycarbonyl)piperidine (306 mg) and 4-chloromethyl-2-(3,4-dimethoxyphenyl)pyridine (264 mg) were condensed in the same manner as described in Example 9 to give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06867221B2
Source dataset	uspto-grants-2005_03
ORD ID	ord-0c2d164145564ca0b879111079f32197
Source note	uspto-grants-2005_03