Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate → HCID 22557598, compound

HRID 984335Notes

Reaction equation

HRID 984335 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5](/[C:8](/[CH3:13])=[C:9](\[CH3:12])/[CH2:10][OH:11])=[CH:4][CH:3]=1.[CH2:14]([O:16][C@@H](CC1C=CC(O)=CC=1)C(OCC)=O)[CH3:15]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5](/[C:8](/[CH3:13])=[C:9](/[CH3:12])\[C:10]([O:16][CH2:14][CH3:15])=[O:11])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 9816147Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 22557552HCID 22557552, compound

Product 1

HCID 22557598HCID 22557598, compoundYield 141.6%

Procedure

The title compound (0.83 g, 87% yield) was prepared from (E)-3-(4-bromophenyl)-2-methyl-but-2-en-1-ol (0.50 g, 2.07 mmol) and (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)-propionate (0.519 g, 2.18 mmol) by a procedure analogous to that described in example 52c.

Sources & evidence

ORD record
ord-37ba9ae7da854acab23c451a5baf566f
Source dataset
uspto-grants-2005_03
Patent number
US06867218B2

Reaction notes

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