Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate → HCID 86589952, compound

HRID 984336Notes

Reaction equation

HRID 984336 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5](/[C:8](/[CH3:13])=[C:9](/[CH3:12])\[CH2:10][OH:11])=[CH:4][CH:3]=1.[CH2:14]([O:16][C@@H:17]([CH2:23][C:24]1[CH:29]=[CH:28][C:27](O)=[CH:26][CH:25]=1)[C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH3:15]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5](/[C:8](/[CH3:13])=[C:9](/[CH3:12])\[CH2:10][O:11][C:27]2[CH:26]=[CH:25][C:24]([CH2:23][C@H:17]([O:16][CH2:14][CH3:15])[C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:29][CH:28]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 9816147Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 69796370HCID 69796370, compound

Product 1

HCID 86589952HCID 86589952, compoundYield 95.3%

Procedure

The title compound (0.91 g, 95% yield) was prepared from (Z)-3-(4-bromophenyl)-2-methyl-but-2-en-1-ol (0.50 g, 2.07 mmol) and (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)-propionate (0.519 g, 2.18 mmol) by a procedure analogous to that described in example 52 c.

Sources & evidence

ORD record
ord-83c2fc5450374fa4bbac1da190e9d45d
Source dataset
uspto-grants-2005_03
Patent number
US06867218B2

Reaction notes

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