Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate → (E)-(S)-Ethyl 2-Ethoxy-3-[4-(3-[1,1';3',1'']terphenyl-4''-yl-but-2-enyloxy)-phenyl]-propionate

HRID 984339Notes

Reaction equation

HRID 984339 reaction equation
[C:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]3[CH:18]=[CH:17][C:16](/[C:19](/[CH3:23])=[CH:20]/[CH2:21][OH:22])=[CH:15][CH:14]=3)[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:24]([O:26][C@@H:27]([CH2:33][C:34]1[CH:39]=[CH:38][C:37](O)=[CH:36][CH:35]=1)[C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH3:25]>>[CH2:24]([O:26][C@@H:27]([CH2:33][C:34]1[CH:35]=[CH:36][C:37]([O:22][CH2:21]/[CH:20]=[C:19](/[C:16]2[CH:15]=[CH:14][C:13]([C:9]3[CH:8]=[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[CH:12]=[CH:11][CH:10]=3)=[CH:18][CH:17]=2)\[CH3:23])=[CH:38][CH:39]=1)[C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH3:25]

Participants

3

Reactant 2

HCID 9816147Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 20765800(E)-3-[1,1';3',1'']terphenyl-4''-yl-but-2-en-1-ol

Product 1

HCID 20765808(E)-(S)-Ethyl 2-Ethoxy-3-[4-(3-[1,1';3',1'']terphenyl-4''-yl-but-2-enyloxy)-phenyl]-propionateYield 80%

Procedure

The title compound (0.41 g, 80% yield) was prepared from (E)-3-[1,1′;3′,1″]terphenyl-4″-yl-but-2-en-1-ol (0.30 g, 1.0 mmol) and (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)-propionate (0.25 g, 1.05 mmol) by a procedure analogous to that described in example 52 c.

Sources & evidence

ORD record
ord-473262b99082486297240b3d97f371f8
Source dataset
uspto-grants-2005_03
Patent number
US06867218B2

Reaction notes

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