Styrene → HCID 73991780, compound

Participants

Reaction Conditions

Reaction Steps

Bu4NBr (2.0 g, 6.3 mmol), K2CO3 (7.8 g, 56.7 mmol), Pd(Oac)2 (250 mg, 1.1 mmol) and styrene (20 mL, 175 mmol) were stirred for 5 min under nitrogen. To the mixture was added 3,5-dibromobenzaldehyde (5.0 g, 18.9 mmol) in dry DMF (5.0 mL), and the mixture was stirred at 65° C. for 16 h. The reaction mixture was diluted with ethyl acetate (20 mL) and the solution filtered. The filtrate was diluted with water and extracted with ethyl acetate (3×50 mL). The organic layers were combined, dried over MgSO4, and concentrated under vacuum. To the residue was added a mixture of toluene/petroleum ether (1:1) (50 mL) and 3,5-distyryl-benzaldehyde (4.95 g, 85%) was isolated by filtration.

Provenance & Evidence