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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 984361Generated: October 30, 2026

Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate → (E)-(S)-Ethyl 3-{4-[3-(2',5'-Dimethoxy-biphenyl-4-yl)-but-2-enyloxy]-phenyl}-2-ethoxy-propionate

https://huagongshe.com/reaction/984361

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 9816147—
Reactant(E)-3-(2',5'-dimethoxy-biphenyl-4-yl)-but-2-en-1-olHCID 69796389—
Product(E)-(S)-Ethyl 3-{4-[3-(2',5'-Dimethoxy-biphenyl-4-yl)-but-2-enyloxy]-phenyl}-2-ethoxy-propionateHCID 8675894561%

Reaction Steps

The title compound (0.765 g, 61%) was prepared as a colourless gum from (E)-3-(2′,5′-dimethoxy-biphenyl-4-yl)-but-2-en-1-ol (0.711 g, 2.50 mmol) and (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)-propionate (0.655 g, 2.75 mmol) by a procedure analogous to that described in example 52c.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06867218B2
Source datasetuspto-grants-2005_03
ORD IDord-1eec3a9df17a4f4bada29e5411a5257a
Source noteuspto-grants-2005_03