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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 984380Generated: October 30, 2026

Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate → (E)-(S)-ethyl 3-{4-[3-(4'-acetyl-biphenyl-4-yl)-but-2-enyloxy]-phenyl}-2-ethoxy-propionate

https://huagongshe.com/reaction/984380

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 9816147—
Reactant(E)-1-[4'-(3-hydroxy-1-methyl-propenyl)-biphenyl-4-yl]-ethanoneHCID 11425603—
Product(E)-(S)-ethyl 3-{4-[3-(4'-acetyl-biphenyl-4-yl)-but-2-enyloxy]-phenyl}-2-ethoxy-propionateHCID 8658995875.4%

Reaction Steps

The title compound (275 mg, 75%) was prepared from (E)-1-[4′-(3-hydroxy-1-methyl-propenyl)-biphenyl-4-yl]-ethanone (200 mg, 0.75 mmol) and (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)-propionate (188 mg, 0.79 mmol) by a procedure analogous to that described in example 52c.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06867218B2
Source datasetuspto-grants-2005_03
ORD IDord-f7995b8417984ada89ac16a2ee65c9be
Source noteuspto-grants-2005_03