Sodium Hydroxide → (E)-(S)-3-{4-[3-(4'-acetyl-biphenyl-4-yl)-but-2-enyloxy]-phenyl}-2-ethoxy-propionic acid

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Reaction Steps

The title compound was prepared from (E)-(S)-ethyl 3-{4-[3-(4′-acetyl-biphenyl-4-yl)-but-2-enyloxy]-phenyl}-2-ethoxy-propionate (Example 107) (200 mg, 0.411 mmol) and sodium hydroxide (1M, 1.64 ml, 1.64 mmol) by a procedure analogous to that described in example 51, yielding (E)-(S)-3-{4-[3-(4′-acetyl-biphenyl-4-yl)-but-2-enyloxy]-phenyl}-2-ethoxy-propionic acid (70 mg, 37%) as a yellow coloured solid.

Provenance & Evidence