Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate → HCID 20765809, compound

HRID 984384Notes

Reaction equation

HRID 984384 reaction equation
[C:1]1([C:7]2[CH:12]=[C:11](/[CH:13]=[CH:14]/[CH2:15][OH:16])[CH:10]=[C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:23]([O:25][C@@H:26]([CH2:32][C:33]1[CH:38]=[CH:37][C:36](O)=[CH:35][CH:34]=1)[C:27]([O:29][CH2:30][CH3:31])=[O:28])[CH3:24]>>[CH2:23]([O:25][C@@H:26]([CH2:32][C:33]1[CH:34]=[CH:35][C:36]([O:16][CH2:15]/[CH:14]=[CH:13]/[C:11]2[CH:12]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:8]=[C:9]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:10]=2)=[CH:37][CH:38]=1)[C:27]([O:29][CH2:30][CH3:31])=[O:28])[CH3:24]

Participants

3

Reactant 2

HCID 9816147Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 22557582HCID 22557582, compound

Product 1

HCID 20765809HCID 20765809, compoundYield 80.1%

Procedure

The title compound (426 mg, 80%) was prepared from (E)-3-[1,1′;3′,1″]terphenyl-5′-yl-prop-2-en-1-ol (300 mg, 1.05 mmol) and (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)-propionate (262 mg, 1.10 mmol) by a procedure analogous to that described in example 52c.

Sources & evidence

ORD record
ord-86b014f65c9546baad1ab69b1b0262c8
Source dataset
uspto-grants-2005_03
Patent number
US06867218B2

Reaction notes

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