Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate → HCID 86589962, compound

HRID 984396Notes

Reaction equation

HRID 984396 reaction equation
[Br:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[CH2:11][OH:12])[CH:5]=[C:6]([Br:8])[CH:7]=1.[CH2:13]([O:15][C@@H:16]([CH2:22][C:23]1[CH:28]=[CH:27][C:26](O)=[CH:25][CH:24]=1)[C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH3:14]>>[Br:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[CH2:11][O:12][C:26]2[CH:25]=[CH:24][C:23]([CH2:22][C@H:16]([O:15][CH2:13][CH3:14])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:28][CH:27]=2)[CH:5]=[C:6]([Br:8])[CH:7]=1

Participants

3

Reactant 2

HCID 9816147Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoateHCID 16215690HCID 16215690, compound

Product 1

HCID 86589962HCID 86589962, compoundYield 78%

Procedure

The title compound (780 mg, 78%) was prepared from (E)-3-(3,5-dibromophenyl)-prop-2-en-1-ol (584 mg, 2.0 mmol) and (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)-propionate (500 mg, 2.10 mmol) by a procedure analogous to that described in example 52c.

Sources & evidence

ORD record
ord-47778ed01a0a476e86f9ec6f62bb9216
Source dataset
uspto-grants-2005_03
Patent number
US06867218B2

Reaction notes

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